Targeted Axillary Dissection of lymph nodes after chemotherapy improves staging accuracy of node-positive breast cancer patients

New surgical technique reduces need for invasive surgery in select patients, MD Anderson study finds

Jo-Carolyn Goode | 1/25/2016, 5:16 p.m.
A new procedure developed by surgeons at The University of Texas MD Anderson Cancer Center improves the accuracy of axillary ...
Henry Kuerer, M.D., Ph.D.

Houston, TX -- A new procedure developed by surgeons at The University of Texas MD Anderson Cancer Center improves the accuracy of axillary staging and pathologic evaluation in clinically node-positive breast cancer, and reduces the need for a more invasive procedure with debilitating complications.

The research, published in the Journal of Clinical Oncology, has changed treatment guidelines at the institution for a select group of breast cancer patients with lymph node metastasis, who will now receive Targeted Axillary Dissection (TAD).

The TAD procedure involves removing sentinel lymph nodes, as well as additional cancerous lymph nodes found during diagnosis. At the time of diagnosis, those select nodes are clipped for identification during later surgery.

Each year, more than 60,000 women with breast cancer are diagnosed with axillary metastasis. Until recently, the standard of care was for these patients to undergo a complete axillary lymph node dissection (ALND) under the arm.

ALND is one of the most challenging procedures for breast cancer patients to recover from and can have lifelong effects, explained Abigail Caudle, M.D., assistant professor, Breast Surgical Oncology at MD Anderson, and the study’s first author. Patients can experience complications such as numbness and lymphedema – an often debilitating swelling of the arm.

Yet, with the addition of chemotherapy before surgery, neoadjuvant chemotherapy, research has shown that approximately 40 percent of these patients have no evidence of disease in their lymph nodes, and therefore would not need the invasive surgery to remove lymph nodes that no longer contain cancer metastases.

“As chemotherapy is utilized more often before surgery, there is a greater likelihood that the disease in the lymph nodes will be eradicated and surgeons do not need to perform extensive nodal surgery,” explains Caudle.

The challenge, says Caudle, is that surgeons haven’t had a way to identify those patients for whom chemotherapy has resulted in this nodal change, so far too many women have undergone the more invasive surgery.

Several studies have shown that sentinel lymph node dissection (SLND), the less-invasive removal of one or a few key lymph nodes, shows promise in assessing disease status, yet the procedure alone can miss residual disease in 10-15 percent of women, defined as a false negative rate (FNR).

“We just haven’t had a good way to determine which patients have converted to node-negative status, and thereby, we are subjecting too many women to unnecessary surgery,” said Caudle. “With our study, we hoped to find a new way to target the lymph node known to have cancer, selectively remove it, look at it, and hopefully avoid additional surgery if chemotherapy has wiped out all the cancer.”

For the prospective single-institution study, 208 breast cancer patients with axillary metastasis were enrolled. When patients underwent their first ultrasound and biopsy at the time of diagnosis, radiologists placed a clip in the cancerous node. They then underwent chemotherapy.

To help locate the specific nodes during surgery, small radioactive seeds were implanted in the clipped node the day before. During surgery, pathologists would then determine the specific pathology of the clipped node to see how it related to other nodes.