Updated: 13 APR 21 10:09 ET

By Elizabeth Cohen and Jacqueline Howard, CNN

(CNN) -- The US Centers for Disease Control and Prevention and the US Food and Drug Administration are recommending that the United States pause the use of Johnson & Johnson's Covid-19 vaccine over six reported US cases of a "rare and severe" type of blood clot.

The six reported cases were among more than 6.8 million doses of the Johnson & Johnson vaccine administered in the United States.

All six cases occurred among women between the ages of 18 and 48, and symptoms occurred 6 to 13 days after vaccination, according to a joint statement on Tuesday from Dr. Anne Schuchat, principal deputy director of the CDC and Dr. Peter Marks, director of the FDA's Center for Biologics Evaluation and Research.

"CDC will convene a meeting of the Advisory Committee on Immunization Practices (ACIP) on Wednesday to further review these cases and assess their potential significance," the statement said. "FDA will review that analysis as it also investigates these cases. Until that process is complete, we are recommending a pause in the use of this vaccine out of an abundance of caution. This is important, in part, to ensure that the health care provider community is aware of the potential for these adverse events and can plan for proper recognition and management due to the unique treatment required with this type of blood clot."

Johnson & Johnson issued a statement on Tuesday noting that the company has decided to "proactively delay the rollout" of its vaccine in Europe.

"We have been working closely with medical experts and health authorities, and we strongly support the open communication of this information to healthcare professionals and the public," the statement said in part.

For people who have received the Johnson & Johnson shot, those who have developed severe headache, abdominal pain, leg pain or shortness of breath within three weeks after vaccination should contact their health care provider, according to the statement.

The statement also noted that these adverse events "appear to be extremely rare."

"It's a very rare event. You're talking about 1 per million, and when you give millions of doses of vaccines, you will see events like this that you couldn't see in the clinical trial just because you didn't have millions of people enrolled," Dr. Carlos del Rio, executive associate dean of the Emory University School of Medicine at Grady Health System, told CNN's John Berman and Poppy Harlow on Tuesday morning.

"But I want to congratulate the CDC and the FDA for very quickly jumping on it, halting the vaccinations until we know more, and really trying to understand what's going on," del Rio said. "I think vaccine safety has always been a priority -- and I think this is exactly the right move until we understand what's going on and what's the way forward."

Del Rio added that the blood clotting may be connected to how the Johnson & Johnson vaccine is an adenovirus vector vaccine -- the same type as AstraZeneca's coronavirus vaccine.

The AstraZeneca vaccine isn't in use in the United States, but has been authorized in more than 70 countries. The European Medicines Agency recently concluded that unusual blood clots with low blood platelets should be listed as "very rare side effects" of the AstraZeneca vaccine. While advising the public to look out for the signs of clots, the regulators said the benefits of the shot were still worth the risk.

"The adenovirus vector vaccine may have something to do with it," del Rio said. The two other Covid-19 vaccines authorized for emergency use in the United States -- Pfizer's and Moderna's -- are mRNA vaccines, which are a different type.

He added that he still recommends people to get vaccinated against Covid-19.

Federal health channels to stop using J&J vaccine immediately

The new announcement from the FDA and CDC means all federal health channels -- mass vaccination sites, community health centers and the like -- that were previously administering the Johnson & Johnson vaccine will immediately stop for the time being, according to a federal health official.

The agencies are recommending that states do the same, but it will be up to the individual states to make that decision because they are given a separate allocation of doses.

The pause happened because this type of blood clot is not listed on the list of potential adverse side effects that were part of the emergency use authorization for J&J. While officials are stressing it is rare, they want health care providers to have time to understand what potential side effects are and how to best treat them.

The CDC and FDA came to a decision late last night, a federal health official said.